TIME TO RECOVERY OF NEONATAL SEPSIS AND DETERMINANT FACTORS AMONG NEONATE ADMITTED AT NICU IN PUBLIC COMPREHENSIVE SPECIALIZED HOSPITALS IN SOUTH NATION NATIONALITY AND PEOPL`S REGIONAL STATE, ETHIOPIA, 2023

Abstract

Background:-Neonatal sepsis is a clinical syndrome of bacteraemia characterized by systemic signs and symptom of infection in the first 28 days of life. Several studies were assessed the magnitude and associated factors of neonatal sepsis but there was a limited data on recovery time of neonatal sepsis. Therefore, this study aimed to assess the recovery time of neonatal sepsis among neonates admitted to the neonatal intensive care unit of public comprehensive specialized hospitals which is not well known. Objective:-The objective of this study was to assess time to recover of neonatal sepsis and its determinant factors among admitted neonates at NICU in selected public comprehensive specialized of SNNPRS, Ethiopia, 2023. Method:-A retrospective follow up study was conducted among 643 charts of neonates with neonatal sepsis who was admitted in NICU at public comprehensive specialized hospitals in SNNPRS from 1st January 2021 to January 1st , 2023 using systematic random sampling. Kaplan Meier curve and log-rank were used to estimate recovery time and to compare the probability of survival time. Cox Proportional Hazard regression model was used. Variables with p-value < 0.05 in multivariable analysis using the cox proportional hazard model was stated as statistically significant predictors of recovery from neonatal sepsis. Result: The overall median recovery time was 8 days. The incidence rate of recovery from neonatal sepsis was 9.86 per 100 neonate day’s observation and the recovery rate of neonate admitted with neonatal sepsis was 83.2%. The factors significantly associated with recovery time of neonatal sepsis includes; respiratory distress (AHR: 0.71, 95% CI (0.59, 0.85)), resuscitation at birth (AHR: 0.65, 95% CI (0.49, 0.87)), having fever (AHR: 0.82, 95% CI (0.67, 0.99)) and frequency of antibiotics change (AHR: 2.0, 95% CI (1.57, 2.63)). Conclusion: The time to recovery from neonatal sepsis was significantly affected by resuscitation at birth, respiratory distress, having fever and frequency of antibiotics change. Therefore, giving special attention to neonates with identified predictors is for their recovery